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appswe ps1de9 app  (Jackson Laboratory)

 
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    Jackson Laboratory appswe ps1de9 app
    Appswe Ps1de9 App, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 86 stars, based on 1 article reviews
    appswe ps1de9 app - by Bioz Stars, 2026-10
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    Related Articles

    Transgenic Assay:

    Article Title: Effects of cranial X-ray irradiation in Presymptomatic 3 × Tg-AD mice.
    Article Snippet: Background: Recently, several animal studies have demonstrated the therapeutic potential of low-dose radiation therapy (LDRT) for Alzheimer’s disease (AD), especially in decreasing amyloid-beta (Aβ) plaques.. However, clinical concerns regarding the duration of efficacy and long-term safety of this treatment remain understudied.. Additionally, LDRT has been shown to alleviate various neurological disorders.

    Article Title: ICP-MS for Multiplexed Protein Determination in Extracellular Vesicles from APP/PS1 Mice Blood Serum–Application to a Zn Supplementation Pilot Study
    Article Snippet: .. APP/PS1 double transgenic mice B6.Cg-Tg (APPswe,PSEN1dE9) 85Dbo/ Mmjax (initially obtained from The Jackson Laboratory, JAX stock #34832) were used in the present study. ..

    Article Title: Expression of amyloid-β antibody via AAV of CNS tropism alleviates Alzheimer’s disease in mice
    Article Snippet: .. B6;C3-Tg (APPswe,PSEN1dE9)85Dbo/Mmjax (APP/PS1) transgenic mice were procured from The Jackson Laboratory and propagated through breeding with C57BL/6 mice (MMRRC Strain #034829-JAX)( ). .. Additionally, B6SJL-Tg (APPSwFlLon, PSEN1*M146L*L286V)6799Vas/Mmjax (5xFAD) mice were procured from The Jackson Laboratory and propagated through breeding with C57BL/6 mice (MMRRC Strain #034840-JAX)( ).

    Construct:

    Article Title: Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer’s disease
    Article Snippet: .. Strain, strain background construct ( M. musculus ) , APP/PS1, APPswe,PSEN1de9 , The Jackson Laboratory , Stock number 004462, RRID: MMRRC_034829-JAX , Male. .. Strain, strain background ( M. musculus ) , PV-Cre, B6.129P2-Pvalbtm1(cre)Arbr/J , The Jackson Laboratory , Stock number 017320 RRID: IMSR_JAX:017320 , Male.

    Mutagenesis:

    Article Title: Trehalose Reduces the Secreted Beta-Amyloid Levels in Primary Neurons Independently of Autophagy Induction.
    Article Snippet: .. We used the double-transgenic mouse strain B6.Cg-Tg (APPSwe, PSEN1dE9) 85Dbo/J, which overexpresses the human genes APP (amyloid beta precursor protein), with the Swedish mutation and exon-9-deleted PSEN1 (presenilin 1; Jackson Laboratory, Bar Harbor; ME, USA, stock no. 005864), hereafter referred to as APP/PSEN1 [45,46]. ..

    Article Title: Mathematical Framework for Quantifying Delocalization in MALDI-MSI via a Composite Scoring Approach
    Article Snippet: .. The mouse strain used for this research project, B6; 129-Tg(APPSwe, tauP301L)1Lfa Psen1tm1Mpm/Mmjax, RRID:MMRRC_034830-JAX, was obtained from the Mutant Mouse Resource and Research Center (MMRRC) at The Jackson Laboratory, an NIH-funded strain https://doi.org/10.1021/acsmeasuresciau.5c00148 ACS Meas. ..

    other:

    Article Title: IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer’s disease mouse model
    Article Snippet: resource Designation Source or reference Identifiers Additional information chemical compound, drug KH2PO4 Applichem Lot: 4Q016683 chemical compound, drug Methoxy- XO4 Abcam ab142818 chemical compound, drug MgSO4 Applichem Lot: 3E000057 chemical compound, drug NaCl Applichem Lot: 8Q012497 chemical compound, drug NaHCO3 Roth Art.-Nr. HN01.1 chemical compound, drug Permount Mounting Medium Fisher Scientific Cat# SP15- 100 chemical compound, drug Poly- L- lysine solution Sigma- Aldrich CAS# 25988- 63- 0 peptide, recombinant protein Recombinant IL- 37 Moretti et al., 2014 N/A peptide, recombinant protein Recombinant IL- 1β Kim et al., 2013 N/A chemical compound, drug Triton X- 100 Molecular Biology grade BC Applichem Cat# A4975 chemical compound, drug Trypsin- EDTA Solution 10 X Sigma- Aldrich CAS Nr. 9002- 07- 7 chemical compound, drug TWEEN 20 Sigma- Aldrich Cat# P9416 commercial assay or kit Biozym Blue Probe qPCR Kit Separate ROX Biozym Cat# 331456 S commercial assay or kit FD Congo- Red Solution Kit FD NeuroTechnologies, Inc. Cat# PS108 commercial assay or kit FD Rapid GolgiStain Kit FD NeuroTechnologies, Inc. Cat# PK401 commercial assay or kit High- Capacity cDNA Reverse Transcription Kit Thermo Fisher Cat# 4368814 commercial assay or kit Macherey- Nagel NucleoSpin RNA Thermo Fisher Product Code 15373604 commercial assay or kit pegGOLD TriFast Avantor N/A commercial assay or kit ProtoScript II First Strand cDNA Synthesis Kit New England Biolabs Inc. Cat# E6560 strain, strain background (Mus musculus) B6;C3- Tg(APPswe,PSEN1dE9)85Dbo/Mmjax mice The Jackson Laboratory Cat# 005864 strain, strain background (Mus musculus) C57BL/6 J OlaHsd mice Harlan- Winkelmann or Janvier Cat# 057 (H- W) strain, strain background (Mus musculus) Human Interleukin- 37 transgenic mice Nold et al., 2010 N/A Continued on next page Continued Lonnemann et al. eLife 2022;11:e75889.



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    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
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    appswe  (Jackson Laboratory)
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    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
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    appswe psen1de9 transgenic mice  (Jackson Laboratory)
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    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
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    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
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    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
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    appswe ps1deltae9 de9 transgenic mice  (Jackson Laboratory)
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    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
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    Image Search Results


    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = male APP/PS1 (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.

    Journal: bioRxiv

    Article Title: Circadian disruption induces sex-specific Alzheimer’s pathophysiology and immune cell reprogramming

    doi: 10.64898/2026.04.30.721994

    Figure Lengend Snippet: (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = male APP/PS1 (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.

    Article Snippet: Hemizygous APPswe/PS1dE9 (APP/PS1) mice and non-transgenic littermate controls were obtained from Jackson Laboratory.

    Techniques: Expressing

    A diagrammatic summary of the effects of CD on macrophage circadian function and early AD-related pathology. Standard lighting conditions are depicted by a normal clock (top left), while the CD condition is represented by a distorted clock with misaligned hands (top right). Pictorial representations of male (♂; top row; solid lines) and female (♀; bottom row; dashed lines) APP/PS1 (AP) mouse macrophages, brains, and circadian proteomic oscillations are shown under standard and disrupted lighting conditions (CD/AP). Macrophages and brains appear pink when naïve and red/darker with increased inflammation states. The black dashed arrow indicates peripheral macrophage trafficking toward the brain. Brown tangles represent relative amyloid-β plaque burden. Representative circadian oscillations illustrate average phase relationships and CD-induced phase shifts. Arrows above the oscillations denote the direction and relative magnitude of phase change under CD/AP conditions compared with AP alone. The width of the shaded traces represents the alignment of the phases of the proteins within immunometabolic pathways. “Immunometabolic phase alignment” indicates increased temporal alignment of immunometabolic pathways in female CD/AP macrophages.

    Journal: bioRxiv

    Article Title: Circadian disruption induces sex-specific Alzheimer’s pathophysiology and immune cell reprogramming

    doi: 10.64898/2026.04.30.721994

    Figure Lengend Snippet: A diagrammatic summary of the effects of CD on macrophage circadian function and early AD-related pathology. Standard lighting conditions are depicted by a normal clock (top left), while the CD condition is represented by a distorted clock with misaligned hands (top right). Pictorial representations of male (♂; top row; solid lines) and female (♀; bottom row; dashed lines) APP/PS1 (AP) mouse macrophages, brains, and circadian proteomic oscillations are shown under standard and disrupted lighting conditions (CD/AP). Macrophages and brains appear pink when naïve and red/darker with increased inflammation states. The black dashed arrow indicates peripheral macrophage trafficking toward the brain. Brown tangles represent relative amyloid-β plaque burden. Representative circadian oscillations illustrate average phase relationships and CD-induced phase shifts. Arrows above the oscillations denote the direction and relative magnitude of phase change under CD/AP conditions compared with AP alone. The width of the shaded traces represents the alignment of the phases of the proteins within immunometabolic pathways. “Immunometabolic phase alignment” indicates increased temporal alignment of immunometabolic pathways in female CD/AP macrophages.

    Article Snippet: Hemizygous APPswe/PS1dE9 (APP/PS1) mice and non-transgenic littermate controls were obtained from Jackson Laboratory.

    Techniques: